Course Title: Invited Symposium 1: Big Data, Little Data: Transforming Neuropsychological Theory, Assessment and Rehabilitation (Evans)

Credit Hours: 1.5

Instructor(s) Jon Evans; Breda Cullen; Szymon Fedor; Justin Miller

Chair: Jon Evans, PhD Clinical Director & Associate Director of Research Oliver Zangwill Centre Princess of Wales Hospital
Invited Symposium 1: Big Data, Little Data: Transforming Neuropsychological Theory, Assessment and Rehabilitation
Summary & Learning Objectives: There is much interest today in discoveries using ‘big data’, yet it’s also true that neuropsychology has a long tradition of studying single cases to develop theories of brain-behaviour relationships. It is likely that the biggest advances in our knowledge will come from harnessing the benefits of both approaches. In this symposium we will showcase methodologies that are transforming our understanding of the neuropsychological consequences of neurological and psychiatric conditions; improving the precision of our assessment of cognitive and emotional functions; and increasing the rigour of our evaluations of neuropsychological interventions. Dr Breda Cullen will illustrate her work with UK Biobank, a community-based cohort of more than 500,000 adults in middle to older age. She will show how research cohorts with clinical, psychosocial, demographic, lifestyle, environmental and genetic data, together with linkage to electronic health records, allow complex relationships between risk factors, mediators and moderators of cognitive impairment in neurological and psychiatric disorders to be modelled using a variety of approaches drawn from predictive (e.g. machine learning) and explanatory (e.g. causal mediation) analytic frameworks. Dr Justin Miller will provide an overview of clinical informatics and the relevance of these concepts to neuropsychology and the measurement of human behavior. He will describe the practical application and benefit of biomedical informatics in the clinical setting and review currently available resources and the potential utility of these applications. Dr Szymon Fedor will discuss the use of another form of big data - the large volume of data obtained from longitudinal, ambulatory measurements collected with wearable sensors and mobile phones. He will show how these complex data are being used to support the assessment of depression severity. Arguing that small is still beautiful, Dr Jon Evans will discuss key recent developments in Single Case Experimental Design (SCED) methodology that mean that these techniques are well-placed to make a much greater contribution to the evidence base of neuropsychological interventions including: (1) statistical techniques with online, easy to use, programs suitable for the analysis of short time series SCED data; (2) a rating tool for the evaluation of SCED study quality; (3) the Single-Case Reporting Guideline in Behavioural Interventions (SCRIBE) reporting standards. Neuropsychology can, and should, join the big data revolution, but at the same time remain loyal to the study of single cases which will continue to inspire developments in theory and practice. Upon conclusion of this course, learners will be able to:
    • Discuss the benefits and challenges of using large cohort data sets to understand the risk factors, mediators and moderators of cognitive impairment in neurological and psychiatric conditions
    • Describe the basic principles of clinical informatics, the potential opportunities to incorporate informatics tools in clinical practice and the utility of informatics tools in evidence-based practice
    • Explain how data from the intensive longitudinal study of individuals can improve assessment of psychological constructs and evaluate the efficacy of neuropsychological interventions
Chair's Biography: Jon Evans is Professor of Applied Neuropsychology at the University of Glasgow and honorary Consultant Clinical Psychologist with NHS Greater Glasgow and Clyde. Jon was the first Clinical Director of the Oliver Zangwill Centre for Neuropsychological Rehabilitation in Ely, Cambridgeshire. In 2000 he was awarded the May Davidson Award by the British Psychological Society in recognition of his outstanding contribution to the development of clinical psychology within 10 years of qualification. He is now Programme Director for the Clinical Neuropsychology programme at the University of Glasgow. Jon has published more than 170 papers, books and book chapters. He is a past Board Member of the International Neuropsychological Society and current chair of the INS International Liaison Committee. He is an Executive Editor of the journal Neuropsychological Rehabilitation and is a co-author of the Behavioural Assessment of the Dysexecutive Syndrome and the Cambridge Prospective Memory Test. In 2018 Jon was awarded Fellowship of the British Psychological Society and awarded the BPS Barbara Wilson Lifetime Achievement Award for outstanding contribution to clinical neuropsychology. Dr. Illes is Professor of Neurology and Canada Research Chair in Neuroethics at the University of British Columbia. She was appointed to the Order of Canada in December 2017.
Presenters: Speaker Biography:
Breda Cullen, PhD
After obtaining her BA Hons (2000) and MSc (2002) in psychology from Trinity College Dublin, Dr Cullen worked in research posts in Ireland, Australia and New Zealand, primarily in the area of dementia and old age psychiatry. She completed her clinical psychology training in Glasgow, specialising in neuropsychology and rehabilitation, then worked clinically in acute neurosciences and rehabilitation services. She holds a Doctorate in Clinical Psychology (2006) and a PhD in psychiatric epidemiology (2018), and is a member of the BPS Specialist Register of Clinical Neuropsychologists. In her current academic role at the University of Glasgow, Dr Cullen's research focuses on the epidemiology and assessment of cognitive function in psychiatric and neurological conditions. She is particularly interested in applying causal inference methods to understand the risk factors and mediating processes that may explain variation in cognitive function. She works closely with other researchers at the University of Glasgow and elsewhere on UK Biobank research. Dr Cullen is also involved in research on psychological therapies and rehabilitation in neurological conditions.
Szymon Fedor, PhD
Szymon Fedor leads several studies at MIT Media Lab where he uses Affective Computing and body-worn devices to study mental health illnesses. He has over fifteen years of research related to wearable technologies and embedded systems. Prior to his current appointment, he carried out research in Ericsson and United Technologies Research Center, contributing to commercial solutions based on consumer electronics. He holds a M.Sc. in Telecommunications with First Class Honours and a Ph.D. in Computer Science. He published a book, a book chapter and over 20 papers in peer reviewed journals and conferences. He also holds seven patents.
Justin Miller, PhD
Dr. Justin Miller is a board-certified clinical psychologist with specialization in neuropsychology and rehabilitation. His graduate training at Wayne State University in Detroit, Michigan focused on recovery of function following neurological injury and he completed his internship and fellowship at the UCLA Semel Institute for Neuroscience and Human Behavior, where he worked with a complex neurological population including movement disorder, brain tumor, epilepsy and neurodegenerative disease. He is currently an associate professor of medicine at the Cleveland Clinic Lerner College of Medicine and director of neuropsychology at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada. Dr. Miller’s clinical practice involves the assessment of patients’ cognitive functioning, and integrating their cognitive profile with relevant medical, psychological and psychosocial factors in order to help with diagnosis and formulation of appropriate treatment strategies. He works with an array of neurological disorders including Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, movement disorders, and multiple sclerosis. He also works with active and retired professional athletes, managing both the acute effects of concussion and return-to-play, as well as, studying the long term effects of repeated head trauma. His primary research endeavors have focused on psychometric study of cognitive assessment practices, specifically as applied to measurement of psychological constructs, including performance validity, technology integration, and biomedical informatics.