Course Title: Invited Symposium 4: Truly Cross Fit: The Association of Exercise and Cognitive Reserve (Smith)


Credit Hours: 1.5


Instructor(s) Glenn Smith; Vonetta Dotson; Aliyah Snyder; Jill Barnes; Kaitlin Casaletto;


Chair: Glen Smith, PhD Elizabeth Faulk Professor and Chair Department of Clinical and Health Psychology, University of Florida Emeritus Professor of Psychology, Mayo College of Medicine
Invited Symposium 4: Truly Cross Fit: The Association of Exercise and Cognitive Reserve
Summary & Learning Objectives: Epidemiological and intervention studies suggest that physical exercise enhances cognition across the lifespan, but is this true in clinical populations? And if is true, what are the mechanisms and are they constant across age and sex? In the first presentation Dr. Vonetta Dotson will examine the mixed evidence for the benefits of exercise on cognitive functioning in depression but promising evidence for depression in late life. She will consider moderators of the exercise-cognition relationship, possible neurobiological mechanisms, and their implications for other non-pharmacological depression treatments. In the second talk Dr. Aliyah Snyder will consider the emergent literature investigating the complex role of exercise following concussion, from acute to chronic injury. The biopsychosocial mechanisms for exercise as a potentially harmful and/or helpful intervention will be presented along with current protocols for post-concussion exercise programs. Next, Dr. Jill Barnes, an Exercise Physiologist, will examine how age-associated impairments in vascular function may be attenuated or even reversed through lifestyle behaviors. This talk will discuss the potential physiological mechanisms underlying the association between exercise and cognition, as well as recent studies evaluating the effect of exercise interventions on the cerebral circulation. Finally, Dr. Kaitlin Casaletto will examine the moderating role of sex on the relationship between physical activity and systemic and brain health related outcomes. She will describe interactions between sex, physical activity, chemokine markers, blood pressure, parahippocampal volumes, and cognition. She will present how the expected beneficial relationship between physical activity and systemic or CNS markers is attenuated in women. Symposium chair Dr. Glenn Smith will discuss research and practice implication of these presentations. Upon conclusion of this course, learners will be able to:
    • Describe research evidence for exercise impacts on cognition in clinical populations
    • Explain the vascular physiology associated with improved cognition
    • Discuss the mechanisms for sex specific attenuation of exercise impacts on cognition
Chair's Biography: Dr. Glenn E. Smith is Chair and Elizabeth Faulk Professor of the Department of Clinical and Health Psychology at the University of Florida. He is Professor Emeritus of Psychology at the Mayo Clinic College of Medicine. A board-certified neuropsychologist, Dr. Smith has authored or co-authored over 200 original articles, 14 book chapters, and 2 books on the neuropsychology of cognitive aging and dementia. He received his Ph.D. in clinical psychology from the University of Nebraska, an internship at UCLA and a fellowship in clinical neuropsychology at the Mayo Clinic in Minnesota, where he subsequently spent 25 years. He is the co-creator of the HABIT® Healthy Action to Benefit Independence and Thinking program, which is designed to benefit people diagnosed with Mild Cognitive Impairment (MCI). He is past president of the American Psychological Association’s (APA) Society of Clinical Neuropsychology, and the American Board of Clinical Neuropsychology, and past Chair of the APA Committee on Aging.
Presenters: Speaker Biography:
Jill Barnes, PhD
Dr. Jill Barnes, Ph.D. is an Assistant Professor in the Department of Kinesiology at the University of Wisconsin-Madison, with an affiliate faculty appointment in the School of Medicine and Public Health. Dr. Barnes received her undergraduate degree University of Michigan, her master’s degree and PhD degrees in Exercise Physiology from the University of Texas at Austin, and completed a postdoctoral fellowship in Integrative Physiology at Mayo Clinic. Her laboratory focuses on understanding blood flow regulation in humans. More specifically her research investigates the effect of aging on vascular health, as well as the potential benefit of habitual exercise. Her current projects investigate the control of cerebral blood flow and how this may impact cognition with advancing age. Dr. Barnes has been funded by NIH, the Alzheimer’s Association, and the American Heart Association. She has received New Investigator awards from both the American Physiological Society and Mayo Clinic and is a Fellow of the American College of Sports Medicine. She teaches undergraduate and graduate exercise physiology courses within the Department of Kinesiology.
Kaitlin B. Casaletto, PhD
As an Assistant Professor of Neuropsychology at the UCSF Memory and Aging Center, I am developing a research program examining how lifestyle behaviors (e.g., physical exercise, mental stimulation) can be leveraged to shape age-related brain health. I am particularly interested in better characterizing the types of activities and understanding the molecular mechanisms that underlie the relationships between lifestyle and brain outcomes in both typical and abnormal aging. My current work (NIA K23) focuses on the use of biofluid markers of neural, immune, and vascular functioning as intermediate outcomes of healthy lifestyle behaviors. My long-term goal is to develop biologically-informed behavioral interventions that promote cognitive resilience and prevent age-related neurodegenerative diseases.
Vonetta Dotson, PhD
Dr. Vonetta Dotson is an Associate Professor of Psychology and Gerontology and director of the Brain Health Clinic at Georgia State University. She completed her doctoral training in clinical psychology at the University of Florida with a specialization in neuropsychology and a certificate in gerontology. She completed her postdoctoral training at the National Institute on Aging Intramural Research Program. Her research and clinical activities focus on the intersection of depression with cognitive and brain aging. She also conducts studies on the impact of physical exercise on depression-related cognitive and brain changes in older adults.
Aliyah Snyder, PhD
Dr. Aliyah Snyder is a licensed clinical psychologist in private practice in Los Angeles and a neuropsychology research fellow at the UCLA Steve Tisch BrainSPORT Program where she studies ways of improving recovery after acquired brain injury/concussion. Specifically, her research focuses on the role of autonomic dysfunction after concussion and the impact of biobehavioral interventions for patients with persistent post-concussion symptoms. Dr. Snyder received her doctoral degree in the neuropsychology track of the clinical and health psychology program at University of Florida. While at UF, Dr. Snyder completed a predoctoral training fellowship in clinical and translational science (CTSI TL1) and founded Athlete Brain, a student-run organization dedicated to promoting concussion safety and awareness in the community. Her doctoral dissertation studied the effects of an aerobic exercise intervention implemented in a post-acute time frame after concussion. Dr. Snyder completed her clinical post-doctoral/fellowship training in the brain injury and sports neuropsychology track at UCLA in the Department of Psychiatry and Biobehavioral Sciences and the UCLA Steve Tisch BrainSPORT Program.