Invited symposia are included in the general meeting registration fee, and as such, are open to ALL registered meeting attendees (there is no additional fee required).
Each of the six invited symposia in this year's program are described in detail below, in their order of appearance.
Thursday February 2, 2017
Invited Symposium 1. Electrical Brain Stimulation and Cognitive Disorders
Thursday February 2, 9:00-10:30 AM in Carondelet (Grand Ballroom)
Symposium Chair: Marom Bikson
Presenters: Marom Bikson, Adam J. Woods, Leigh Charvet
Symposium Summary: Non-invasive electrical stimulation is investigated to remedy cognitive decline associated with a wide range of neuropsychiatric disorders and brain injury, as well as cognitive aging and neurodegenerative disease. This session focuses on one brain stimulation approach, transcranial Direct Current Stimulation (tDCS) that has emerged as a promising intervention to accelerate response to other cognitive or behavioral treatments. Applications span cognitive disorders of stroke, TBI, MS, epilepsy, chronic pain, and age related deficits. tDCS is considered sufficiently tolerated that human trials on cognitive function even include healthy volunteers. Indeed, it is work in healthy subjects that established the basic mechanisms and plausibility of applying tDCS as a clinical intervention. This session covers the technical basics, mechanisms, and applications of tDCS. Insight from animal studies and human neurophysiology indicate tDCS has the broad capacity to modulate cortical excitability and enhance ongoing plasticity. In its function as an enhancer of ongoing activity; tDCS is used in clinical trials along with cognitive or behavioral training. For example, in the treatment of age- or MS- related cognitive decline, tDCS is applied with computerized “brain games” or “cognitive training” to facilitate the neuroplastic response of brain tissue engaged by challenging cognitive tasks. In TBI and stroke rehabilitation, tDCS is used to as tool to boost the efficacy of neuro-rehabilitation therapy, again under the principle that brain plasticity activated by training will be enhanced by electrical stimulation. This session also address state-of-the-art techniques to enhance the efficacy and deployment of tDCS including use of EEG to guide stimulation, home-base therapies, and focal stimulation with High-Definition tDCS.
Symposium Abstracts Being Presented:
- M. Bikson. Electrical Brain Stimulation and Cognitive Disorders. (SUMMARY)
- M. Bikson, D. Q. Truong. The Basics of tDCS: Technology and Mechanisms
- A. J. Woods. Combating Cognitive Aging and Dementia with Transcranial Direct Current Stimulation (tDCS)
- L. E. Charvet, M. Shaw. At-Home Access: Extending Clinical Trials of Cognitive Remediation and tDCS through Remote Supervision
Chair's Biography: Dr. Marom Bikson is a Cattell Professor of Biomedical Engineering at The City College of New York (CCNY) of the City University of New York (CUNY) and co-Director of the Neural Engineering Group at the New York Center for Biomedical Engineering. The translational R&D activity of his group spans pre-clinical studies, computational models, device design and fabrication, regulatory activities, and clinical trials. Technologies developed by his group are in clinical trials in over 250 medical centers and include neuromodulation interventions for neuropsychiatric disorders, intra- and post-operative sensors, patient compliance tools, and surgeon training simulators. Dr. Bikson has published over 200 papers and book-chapters and is inventor on over 30 patent applications. He is known for his work on brain targeting with electrical stimulation, cellular physiology of electric effects, and electrical safety. Dr. Bikson co-invented High-Definition transcranial Direct Current Stimulation (HD-tDCS), the first non-invasive, targeted, and low-intensity neuromodulation technology. Dr. Bikson consults for medical technology companies and regulatory agencies on the design, validation, and certification of medical instrumentation. Dr. Bikson is co-founder of Soterix Medical Inc. Prior to becoming faculty at CUNY, Dr. Bikson was a research fellow at the University of Birmingham Medical School, UK and a Research Associate at Sontra Medical LLC, in Cambridge Mass. Dr. Bikson received a Ph.D. in Biomedical Engineering from Case Western Reserve University, in Cleveland OH, and a B.S. in Biomedical Engineering from Johns Hopkins University, Baltimore.
Invited Symposium 2. Evolution of the Neuropsychology of Epilepsy Surgery
Thursday February 2, 12:45-2:15 PM in Carondelet (Grand Ballroom)
Symposium Chair: Bruce Hermann
Presenters: Bruce Hermann, Jeffrey Ojemann, Marla J. Hamberger, Daniel L. Drane, Carrie McDonald
Symposium Summary: Clinical and experimental neuropsychology has had a long and productive relationship with the field of epilepsy surgery beginning with its earliest days at the Montreal Neurological Institute. As the availability of surgical treatment for medication resistant epilepsy spread throughout the world, neuropsychology has remained a standard component in the evaluation of patients for surgical consideration as well as the evaluation of outcomes following surgery. The resulting clinical and experimental work has contributed to new knowledge regarding brain function, served to characterize patient groups at high and low risk for postoperative cognitive and behavioral complications, and helped to inform advances in surgical approaches and techniques. The 50th anniversary of the International Neuropsychological Society is an appropriate time to take stock of the advances in epilepsy surgery and the neuropsychology of epilepsy surgery that have taken place over this interval. The symposium will begin with an overview of epilepsy surgery and the advances in care and technique occurring over time (Jeffrey Ojemann, MD, University of Washington), followed by speakers who will address the evaluation and outcomes across major cognitive domains including language (Marla Hamberger, PhD, Columbia University), memory (Dan Drane, PhD, Emory University), and executive function (Carrie McDonald, PhD, UCSD). Each speaker will provide a historical perspective of the changes in style, approach and outcome that have occurred over time as well as the latest findings with a view to future directions and opportunities.
Symposium Abstracts Being Presented:
- B. Hermann, J. Ojemann, M. J. Hamberger, D. L. Drane, C. McDonald. Evolution of the Neuropsychology of Epilepsy Surgery (SUMMARY)
- J. Ojemann. On the Evolution of Neurosurgery and Neuropsychology in Epilepsy: Epilepsy Surgery
- M. J. Hamberger. On the Evolution of Neurosurgery and Neuropsychology in Epilepsy: Language
- D. L. Drane. On the Evolution of Neurosurgery and Neuropsychology in Epilepsy: Memory
- C. McDonald. On the Evolution of Neurosurgery and Neuropsychology in Epilepsy: Executive Functions
Chair's Biography: Bruce Hermann, PhD, APBB-CN is Professor and Director of the Charles Matthews Neuropsychology Section in the Department of Neurology at the University of Wisconsin School of Medicine and Public Health. His primary clinical and research interests include the etiology and natural history of cognitive and behavioral problems in children and adults with epilepsy as well as the neurobehavioral outcomes of epilepsy surgery. He currently serves on the Board of Directors of the American Epilepsy Society and is Treasurer of the International Neuropsychological Society.
Friday, February 3, 2017
Invited Symposium 3. Advances in Pediatric Mild TBI: Toward a Neurobiopsychosocial Model
Friday February 3, 9:00-10:30 AM in Carondelet (Grand Ballroom)
Symposium Chair: Keith O. Yeates
Discussant: H. Gerry Taylor
Presenters: Keith O. Yeates, Alain Ptito, Vicki Anderson, Michael Kirkwood
Symposium Summary: Pediatric mild traumatic brain injury (mTBI), including concussion, is a significant public health problem, with the number of children seeking medical care rising dramatically. This symposium will summarize research on pediatric mTBI, including concussion, with the aim of highlighting the need for a multi-level, multi-dimensional approach to understanding and managing children with these injuries. The symposium will begin with a brief introduction by Keith Yeates, to provide a historical context, and then be followed by four speakers presenting on various aspects of assessment and management of mTBI and a discussant. Alain Ptito will discuss neuroimaging as a diagnostic and prognostic tool. Keith Yeates will discuss neuropsychological testing as a predictor and outcome of pediatric mild TBI. Vicki Anderson will address psychosocial predictors of and influences on outcomes. Michael Kirkwood will describe neuropsychological assessment as an intervention model in pediatric concussion. Gerry Taylor will act as discussant, integrating the themes that emerge from the individual presentations and highlighting future directions for research on mTBI. The symposium will conclude with an audience question-and-answer period. The goal of the symposium is to provide insights into recent advances in this important and developing area of research and to stimulate further scientific progress by promoting a neurobiopsychosocial model of pediatric mTBI.
Symposium Abstracts Being Presented:
- K. O. Yeates, A. Ptito, V. A. Anderson, M. Kirkwood, H. TayloR. Advances in Pediatric Mild TBI: Toward a Neurobiopsychosocial Model (SUMMARY)
- A. PTITO. Neuroimaging as a Diagnostic and Prognostic Tool in Pediatric Concussion
- K. O. Yeates, E. D. Bigler, A. Bacevice, B. Bangert, D. Cohen, L. Mihalov, N. Zumberge, H. Taylor. Neuropsychological testing as an outcome and predictor in pediatric mild traumatic brain injury
- V. A. Anderson, M. Takagi, S. Bressan, G. Davis, C. Clarke, N. Anderson, S. Hearps, K. Dunne, F. Babi. Psychosocial Predictors of and Influences on Outcomes of Pediatric Concussion
- M. Kirkwood. Neuropsychological Assessment as an Intervention Model in Pediatric Concussion
- H. Taylor. Discussion of Issues and Future Directions
Chair's Biography: Keith Owen Yeates, PhD, RPsych, ABPP-CN, is the Ronald and Irene Ward Chair in Pediatric Brain Injury and Professor in the Departments of Psychology, Pediatrics, and Clinical Neurosciences at the University of Calgary, in Alberta, Canada. He leads the University of Calgary Integrated Concussion Research Program, the Hotchkiss Brain Institute Traumatic Brain Injury NeuroTeam, and the Alberta Children’s Hospital Research Institute Behaviour and Developing Brain Theme. He has received >$15 million in external grant support from NIH, CIHR, and other agencies for his research, which focuses on the outcomes of childhood brain disorders, particularly traumatic brain injury, and has published over 200 peer-reviewed journal articles and book chapters, as well as 5 edited or co-authored books. He has received a number of honors and awards: Fellow of the American Psychological Association (APA); Canadian Association of Child Neurology John Tibbles Lecturer; Visiting Fellow of the Australian Psychological Society; Charles Matthew Lecturer at the University of Wisconsin School of Medicine and Public Health; and the Arthur Benton Award from the International Neuropsychological Society. Dr. Yeates is has served as President of the Society of Clinical Neuropsychology of the American Psychological Association and the Association of Postdoctoral Programs in Clinical Neuropsychology, and is currently President-Elect of the International Neuropsychological Society.
Invited Symposium 4. A Summit on Cognitive Rehabilitation: Mapping the Past, Defining the Present and Imagining the Future
Friday February 3, 1:00-2:30 PM in Carondelet (Grand Ballroom)
Symposium Chair: Anthony Y. Stringer
Presenters: Barbara A. Wilson, Keith D. Cicerone, Anthony Y. Stringer
Symposium Summary: While the treatment of persons with traumatic brain injury can be traced back to the ancient Egyptians, the modern era of cognitive rehabilitation began with World War I and the pioneering work of Kurt Goldstein. Subsequent international conflicts continued to spur the development of rehabilitation programs and strategies into contemporary times. Early work in the field was equal parts art and science, yet such work yielded enduring principles that continue to guide the treatment of persons with neurocognitive impairment. Contemporary clinicians have a growing armamentarium of empirically-supported treatments to address cognitive impairment in an expanding range of patient populations. The future will see an increasing use of pharmacological, genetic, electronic, digital, and neuroprosthetic tools, in addition to the cognitive strategies and techniques that have long been our staple. In this symposium, Dr. Barbara A. Wilson will trace the historical development of cognitive rehabilitation and provide an overview of the enduring principles from the past; Dr. Keith D. Cicerone will review the empirical efficacy of current cognitive rehabilitation strategies and techniques; and Dr. Anthony Y. Stringer will discuss the future of cognitive rehabilitation in an era of advancing pharmacological, genetic, electronic, digital, and neuroprosthetic tools.
Symposium Abstracts Being Presented:
- A. Y. Stringer, B. A. Wilson, K. D. Cicerone. A Summit on Cognitive Rehabilitation: Mapping the Past, Defining the Present and Imagining the Future (SUMMARY)
- B. A. Wilson. The History of Cognitive Rehabilitation
- K. D. Cicerone. The Present Status of Cognitive Rehabilitation
- A. Y. Stringer. The Future of Cognitive Rehabilitation
Chair's Biography: Anthony Y. Stringer, Ph.D., ABPP/ABCN is Professor of Rehabilitation Medicine at Emory University and is the Director of the Division of Rehabilitation Neuropsychology in the Emory University School of Medicine. Dr. Stringer is a board-certified clinical neuropsychologist and has practiced neuropsychology and cognitive rehabilitation for over 30 years. He is a fellow of the American Psychological Association – Society for Clinical Neuropsychology and of the National Academy of Clinical Neuropsychology. He also serves as the current President of the American Board of Clinical Neuropsychology. Dr. Stringer has authored or edited books on neuropsychological diagnosis and the history of neuropsychology, and has published numerous articles, abstracts, and book chapters from his research on neuropsychological syndromes and cognitive rehabilitation outcome. Finally, he is the author of the Ecologically Oriented Neurorehabilitation programs which incorporate a compensatory strategy approach to the rehabilitation of patients with memory or executive function disorders.
Invited Symposium 5. The Next Generation: A Look at Cohort Studies of People at Risk for Alzheimer’s Disease
Friday February 3, 4:00-5:30 PM in Carondelet (Grand Ballroom)
Symposium Chair: Sterling C. Johnson
Presenters: Therese Barry-Tanner, Sterling C. Johnson, Jason Hassenstab, Anja Soldan, Jennifer Manly, Angela Jefferson
Symposium Summary: The pathological processes underlying Alzheimer’s disease (AD) begin years or perhaps decades prior to onset of overt dementia. New findings are emerging from several longitudinal AD-risk enriched cohorts that indicate brain and cognitive changes exist during the preclinical and prodromal phases of AD. The symposium will begin from the ‘at-risk’ participant’s perspective using clips from an upcoming independent documentary film offering an intimate look at AD research entitled “Will I be Next?”. The film follows three middle-aged women who volunteer as research participants in the longitudinal Wisconsin Registry for Alzheimer’s Prevention (WRAP) study. Each of these women has a family history of AD and is at high risk for developing AD in the future (“the next generation”).
The symposium will transition to a discussion of several select risk-enriched longitudinal cohort studies, including a summary of each study’s design, seminal findings, and future directions. Cohorts include the WRAP study (University of Wisconsin, PI: Sterling Johnson, PhD), the Adult Children Study (Washington University, PI: John Morris MD; presented by Jason Hassenstab, PhD), the BIOCARD Study (Johns Hopkins University, PI: Marilyn Albert; presented by Anja Soldan, PhD), the Offspring Study (Columbia University, PI: Jennifer Manly, PhD), and the Vanderbilt Memory and Aging Project (Vanderbilt University Medical Center, PI: Angela Jefferson, PhD). The presentation of seminal findings from these cohorts will focus on neuropsychological and biomarker changes in people at risk for AD, characteristics that may pose resilience against cognitive decline, and implications for participant selection in future prevention trials.
Symposium Abstracts Being Presented:
- S. C. Johnson, T. Barry-Tanner, J. Hassenstab, A. Soldan, J. J. Manly, A. L. Jefferson. The Next Generation: A Look at Cohort Studies of People at Risk for Alzheimer’s Disease (SUMMARY)
- T. Barry-Tanner. Will I Be Next?
- S. C. Johnson. The Wisconsin Registry for Alzheimer’s Prevention (WRAP)
- J. Hassenstab, A. Fagan, J. Morris. Correlating Rates of Change Between Cognition and Biomarkers in Middle Aged Adults at Risk for Alzheimer’s Disease: The Adult Children Study
- A. Soldan, C. Pettigrew, Q. Cai, M. Wang, A. Moghekar, A. Fagan, C. Fowler, C. Carlsson, C. Masters, S. C. Johnson, S. Asthana, J. Morris, A. Gross, M. Albert. Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change
- J. J. Manly, A. M. Brickman. Offspring Study of Mechanisms for Racial Disparities in Alzheimer’s Disease
- A. L. Jefferson. The Vanderbilt Memory & Aging Project: Study Design, Findings, and Future Directions
Chair's Biography: Dr. Johnson is a Professor at the University of Wisconsin where he leads the Wisconsin Registry for Alzheimer’s Prevention, a longitudinal cohort study of people at risk for sporadic AD. He is the Associate Director and Imaging Core Leader within the Wisconsin Alzheimer’s Disease Research Center. His research focuses on the neurobiological and psychological processes that affect memory; and early identification of AD using multiple modalities from cognition to molecular imaging of amyloid and tau.
Saturday, February 4, 2017
Invited Symposium 6. Translational Neuropsychology: Contemplating the Past and Looking Toward the Future
Saturday February 4, 10:00-11:30 AM in Carondelet (Grand Ballroom)
Symposium Chair: Adam M. Brickman
Presenters: Adam M. Brickman, Deanna Barch, Robert Bilder, Rhoda Au, Russell M. Bauer
Symposium Summary: With the celebration of the 50th year anniversary of the International Neuropsychological Society comes the opportunity to reflect on the history of our field and to contemplate the directions we are going. Neuropsychology, at its core, is a multi- and inter-disciplinary field that draws inspiration from cognitive psychology, behavioral neurology, and basic neuroscience to derive brain-behavior relationships and apply them to clinical settings. Early studies used lesion approaches in animals and humans to map behavioral correlates of regional brain damage and, by inference, normal brain functioning. The majority of contemporary studies in neuropsychology apply psychometric assessment to determine cognitive correlates of clinical conditions and developmental stages. Clinical and applied aspects of neuropsychology deploy similar psychometric assessments to aid in diagnosis and treatment recommendations. As we look toward our future, we propose embracing a translational neuropsychology approach, in which we apply methodological and theoretical innovation to elucidate the mechanistic bases of brain-behavioral relationships that support direct translation into clinical practice. This symposium will highlight translational approaches used in five neuropsychology laboratories. Dr. Brickman will discuss work on the integration of neuroimaging and experimental methods to dissociate hippocampal subfields, the cognitive processes they mediate, and associated treatment-focused clinical trials. Dr. Barch will focus on historical concepts of brain connectivity, current conceptions and methods, and future innovations and translations, including stimulation or feedback approaches to enhance connectivity and human/animal parallels. Dr. Bilder will discuss the principle analytic and conceptual models that have driven our understanding of brain and behavior, from past comparisons of “organic” disorders through classic psychometric analyses, to the development of causal models that span multiple biological scales. Dr. Au will discuss how technology integration provides immediate opportunities to create novel cognitive biomarkers and enable a future role for neuropsychology in the realm of big data. Dr. Bauer will discuss a simultaneous animal-human platform developed to examine cortical-hippocampal interactions using MRI, electrophysiology, viral vectors, and human/animal performance.
Symposium Abstracts Being Presented:
- A. M. Brickman, D. M. Barch, R. M. Bilder, R. Au, R. M. Bauer. Translational Neuropsychology: Contemplating the Past and Looking Toward the Future (SUMMARY)
- A. M. Brickman, R. P. Sloan, S. A. Small. Dietary Flavanols, Hippocampal Subfields, and Cognitive Aging: A Translational Neuropsychology Story
- D. M. Barch. Connectomics and the Brain: Past, Present and Future
- R. M. Bilder. Neuropsychological Models: Past, Present and Future
- R. Au, T. Ang. Next Generation Neuropsychology: Digital Biomarkers and Big Data
- R. M. Bauer. An Interactive Translational Platform for Investigating Age-Related Memory Decline
Chair's Biography: Adam Brickman, PhD, is an Associate Professor of Neuropsychology at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center in the Department of Neurology at of Columbia University College of Physicians and Surgeons. Dr. Brickman uses advanced neuroimaging techniques to understand cognitive aging and dementia. He is particularly interested in white matter abnormalities and the intersection between vascular disease and Alzheimer's disease. He was the 2010 recipient of the Early Career Award from Division 40 (Clinical Neuropsychology) of the APA and of the Early Career Research Award from INS.